The Vex Overthrow mission in Destiny 2 presents formidable bosses that can pose significant challenges. Encountering issues such as overwhelming enemy aggression, limited ammo availability, and restrictive architectural layouts can hinder progress. Additionally, unpredictable boss attacks and synchronized defenses require swift adaptation and effective teamwork.

To overcome these challenges, meticulous planning and strategic execution are crucial. Prioritize clearing ads before engaging bosses to reduce distractions. Utilize cover effectively and anticipate boss attacks to avoid unnecessary damage. Coordinate with teammates to distribute ammo efficiently and focus fire on specific targets. Leverage the environment, such as destructible barriers and platforms, to gain tactical advantages. Adapt to evolving boss tactics, employing different weapons and abilities as needed. Effective communication and teamwork will significantly enhance the chances of successfully defeating the Overthrow bosses.